COVID-19 Prediction Infrastructure Using Deep Learning

Coronavirus can lead to respiratory illnesses ranging from mild to severe, and even death, which makes early detection critical. However, current COVID-19 (Coronavirus Disease 2019) detection methods are not only expensive but also time-consuming. This poses a challenge, especially with an increasing number of patients and demand for testing kits. Waiting for test results for a few days is not ideal, as the outbreak can spread quickly in the meantime. To address this issue, we propose a COVID-19 prediction infrastructure using deep learning. This innovative android-based application uses a Convolutional Neural Network model, trained on a custom dataset with an accuracy of 97 percent, to predict whether COVID-19 is present or not. With this fast and low-cost approach, users can quickly detect COVID-19 and take appropriate actions to reduce the risk of transmission

Uma Guerra Inesperada na Ucrânia: O que Devemos Esperar? As Consequências da Guerra entre os Refugiados Ucranianos

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Links Between Painting and Neurology: The Example of Dementia.

Art is a system of human communication arising from symbolic cognition, conveying ideas, experiences, and feelings. The goal of this review is to describe the link between painting and dementia. Individuals with neurodegenerative diseases inevitably experience cognitive dysfunction that has the potential to limit and impair the artist's ability to realize their creative and expressive intentions through painting. The strategy to advance our understanding of the neural bases for art is to map locations and nature of neural damage to changes onto artistic production

Tratamiento combinado de microabrasión de esmalte y blanqueamiento ambulatorio en paciente con fluorosis

La fluorosis dental es una patología causada por la ingesta excesiva de fluoruros durante la formación dental. La prevalencia de fluorosis ha ido en aumento durante los últimos años, no sólo como resultado de la ingesta de agua con exceso del ion flúor, sino también por la amplia disponibilidad de fluoruros a través de diversas fuentes como las aplicaciones profesionales, programas de salud bucal, alimentos y bebidas, entre otros. La microabrasión del esmalte aplicada conjuntamente con otras técnicas blanqueadoras representa una opción de tratamiento bien documentada en importantes bases científicas, con trabajos clínicos comprobados a largo plazo, ofreciendo una interesante alternativa conservadora, efectiva, segura y de rápidos resultados estéticos. Se presenta la aplicación de estas técnicas en un caso clínico donde se eliminaron las manchas de fluorosis utilizando una técnica de blanqueamiento combinado, mediante la aplicación de ácidos y pastas abrasivas para la microabrasión dentaria y geles de peróxido de carbamida para blanqueamiento ambulatorio, consiguiendo por este tratamiento combinado una armonización en el tono del esmalte dental.Facultad de Odontologí

Microabrasión dental : Caso clínico

La resolución estética de los más diversos tipos de alteraciones de color de los dientes representa un gran desafío para el odontólogo. A través del correcto diagnóstico de estas alteraciones, el profesional puede decidir cuál es el mejor tratamiento estético u optar por la asociación de diferentes métodos de tratamiento a fin de alcanzar el resultado más satisfactorio con un mínimo desgaste de las estructuras dentales. En la tentativa de promover mejoras en la estética de la sonrisa, el profesional puede usar técnicas de blanqueamiento en combinación con microabrasión del esmalte como una opción segura y eficaz para la solución de algunas pigmentaciones dentales que afecten sólo el tejido adamantino.Facultad de Odontologí

Blanqueamiento interno

Tratamiento conservador para restaurar la estética en dientes no vitales oscurecidos o manchados. A pesar de los riesgos y dificultades que acompañan esta estética, los dientes no vitales a menudo pueden aclararse con éxito. Esta modalidad surge por la necesidad estética que se vive actualmente en lo que respecta a la boca. Es un tema de mucha discusión ya que la pieza debe cumplir ciertos requisitos para que se lleve a cabo. Existe una demanda cada vez mayor debido a la importancia en la conservación de una pieza dentaría y la estética de la misma. Por lo tanto es preciso indagar más sobre esta modalidad de tratamiento para poder ofrecerles a nuestros pacientes diferentes alternativas para la resolución cosmética de su sonrisa.Facultad de Odontologí

Trajectory of Spike-Specific B Cells Elicited by Two Doses of BNT162b2 mRNA Vaccine

: The mRNA vaccines for SARS-CoV-2 have demonstrated efficacy and immunogenicity in the real-world setting. However, most of the research on vaccine immunogenicity has been centered on characterizing the antibody response, with limited exploration into the persistence of spike-specific memory B cells. Here we monitored the durability of the memory B cell response up to 9 months post-vaccination, and characterized the trajectory of spike-specific B cell phenotypes in healthy individuals who received two doses of the BNT162b2 vaccine. To profile the spike-specific B cell response, we applied the tSNE and Cytotree automated approaches. Spike-specific IgA+ and IgG+ plasmablasts and IgA+ activated cells were observed 7 days after the second dose and disappeared 3 months later, while subsets of spike-specific IgG+ resting memory B cells became predominant 9 months after vaccination, and they were capable of differentiating into spike-specific IgG secreting cells when restimulated in vitro. Other subsets of spike-specific B cells, such as IgM+ or unswitched IgM+IgD+ or IgG+ double negative/atypical cells, were also elicited by the BNT162b2 vaccine and persisted up to month 9. The analysis of circulating spike-specific IgG, IgA, and IgM was in line with the plasmablasts observed. The longitudinal analysis of the antigen-specific B cell response elicited by mRNA-based vaccines provides valuable insights into our understanding of the immunogenicity of this novel vaccine platform destined for future widespread use, and it can help in guiding future decisions and vaccination schedules

B cell response after SARS-CoV-2 mRNA vaccination in people living with HIV

Background: Limited longitudinal data are available on immune response to mRNA SARS-CoV-2 vaccination in people living with HIV (PLWHIV); therefore, new evidence on induction and persistence of spike-specific antibodies and B cells is needed. Methods: In this pilot study we investigated the spike-specific humoral and B cell responses up to six months after vaccination with two doses of mRNA vaccines in 84 PLWHIV under antiretroviral therapy compared to 79 healthy controls (HCs). Results: Spike-specific IgG persisted six months in PLWHIV with no significant differences compared to HCs, even though a significantly lower IgG response was observed in patients with CD4+ T cells < 350/mmc. The frequency of subjects with antibodies capable of inhibiting ACE2/RBD binding was comparable between PLWHIV and HCs a month after the second vaccine dose, then a higher drop was observed in PLWHIV. A comparable percentage of spike-specific memory B cells was observed at month six in PLWHIV and HCs. However, PLWHIV showed a higher frequency of spike-specific IgD- CD27- double-negative memory B cells and a significantly lower rate of IgD- CD27+ Ig-switched memory B cells compared to HCs, suggesting a reduced functionality of the antigen-specific memory B population. Conclusions: The mRNA vaccination against SARS-CoV-2 elicits humoral and B cell responses quantitatively similar between PLWHIV and HCs, but there are important differences in terms of antibody functionality and phenotypes of memory B cells, reinforcing the notion that tailored vaccination policies should be considered for these patients

Percutaneous mitral valve edge-to-edge Repair: In-hospital results and 1-year follow-up of 628 patients of the 2011-2012 pilot European Sentinel Registry

The use of transcatheter mitral valve repair (TMVR) has gained widespread acceptance in Europe, but data on immediate success, safety, and long-term echocardiographic follow-up in real-world patients are still limited

Usability evaluation of touch gestures for Mobile Augmented Reality applications

In recent years, mobile-device apps have become the most common platform for augmented reality contents. The following work aims to identify the best touch-gestures for the interaction with virtual objects in augmented reality apps. An experimental study has been carried out on 80 people aged from 15 to 23 years-old. Three tasks have been evaluated: translation, rescaling and rotation of a 3D object. The considered gestures are: 1-finger tap, 1-finger pan, 2-finger pan, 2-finger rotation, Pinch-to-zoom and the Hold-and-move, which has been designed specifically for augmented reality apps. The goal is to find the best gesture to perform each task, from the point of view of the usability. Both objective and subjective measurements have been performed, to ensure an exhaustive evaluation of the usability. This analysis can help mobile app developers deciding the gestures to use to implement frequent tasks in 3D object’s manipulation